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Marijuana, also known as cannabis or pot, has a long history of human use. Most ancient cultures didn’t grow the plant to get high, but as herbal medicine, likely starting in Asia around 500 BC. The history of cannabis cultivation in America dates back to the early colonists, who grew hemp for textiles and rope. Political and racial factors in the 20th century led to the criminalization of marijuana in the United States, though its legal status is changing in many states.
The cannabis or hemp plant originally evolved in Central Asia before people introduced the plant into Africa, Europe, and eventually the Americas. Hemp fiber was used to make clothing, paper, sails and rope, and its seeds were used as food.
Because it’s a fast-growing plant that’s easy to cultivate and has many uses, hemp was widely grown throughout colonial America and at Spanish missionsin the Southwest. In the early 1600s, the Virginia, Massachusetts and Connecticut colonies required farmers to grow hemp.
These early hemp plants had very low levels of tetrahydrocannabinol (THC), the chemical responsible for marijuana’s mind-altering effects.
There’s some evidence that ancient cultures knew about the psychoactive properties of the cannabis plant. They may have cultivated some varieties to produce higher levels of THC for use in religious ceremonies or healing practice.
Burned cannabis seeds have been found in the graves of shamans in China and Siberia from as early as 500 BC.
Cannabinoids are a diverse set of chemical compounds that bind to special receptors in the human body that make up what is known as the endocannabinoid system. The “key and lock” metaphor is often used to describe this process. The human body possesses specific binding sites (“locks”) on the surface of many cell types, and our body produces several endocannabinoids (“keys”) that bind to these cannabinoid receptors (CB) to activate or “unlock” them.
In 1992, researchers detected an endogenous substance that binds to cannabinoid receptors for the first time. This substance, known as anandamide, comes from the Sanskrit word “Ananda” for bliss and “amide” due to its chemical structure. A second endocannabinoid was discovered in 1995, 2-arachidonoylglycerol (2-AG). These two endocannabinoids are the best studied so far. Today, it is thought that about 200+ related substances exist, which resemble the endocannabinoids and complement their function in what has been termed the “entourage effect.” Several endocannabinoids do not only bind to cannabinoid receptors, but also to a possible CB3 receptor (the GPR55 receptor), to vanilloid receptors and further receptors.
In addition to endocannabinoids, scientists have now identified cannabinoids found in the cannabis plant (phytocannabinoids) that work to mimic or counteract the effects of some endocannabinoids. Phytocannabinoids and terpenes are manufactured in resin glands (trichomes) present on the flowers and main fan leaves of late-stage cannabis plants. The amount of resin produced and its cannabinoid content varies by plant gender, growing conditions and harvesting time. The chemical stability of cannabinoids in harvested plant material is affected by moisture, temperature, light and storage, but will degrade over time in any storage conditions.
When a cannabinoid causes a receptor to act in the same way as it would to a naturally occurring hormone or neurotransmitter, then it is labeled “agonist.” On the other hand, if the cannabinoid prevents the receptor from binding to the naturally occurring compound, thereby causing the resulting event (e.g., pain, appetite, alertness) to be altered or diminished, it is labeled “antagonist.” Research is mounting to better understand how specific cannabinoids can unlock (or lock in some cases) specific receptors.
Over 100 phytocannabinoids have been identified in the cannabis plant, many of which have documented medicinal value. Most are closely related or differ by only a single chemical part. The most talked-about and researched cannabinoids found in the cannabis plant are tetrahydrocannabinol (THC) for its psychoactive properties (“high feeling”) and cannabidiol (CBD) for its healing properties.
Cannabinoids can be administered by smoking, vaporizing, oral ingestion, transdermal patch, intravenous injection, sublingual absorption or rectal suppository.
An Endogenous Cannabinoid System (ECS), commonly referred to as an “Endocannabinoid System,” is found in every animal and regulates a broad range of biological functions. The ECS is a biochemical control system of neuromodulatory lipids (molecules that include fats, waxes, sterols and fat-soluble vitamins such as vitamins A, D, E and K and others) and specialized receptors configured to accept certain cannabinoids. In general, a given receptor will accept only particular classes of compounds and will be unaffected by other compounds, just as a specific key is needed to open a lock.
Specialized receptors are located throughout the human body, including but not limited to, in the hippocampus (memory, learning), the cerebral cortex (decision-making, emotional behavior), the cerebellum (motor control, coordination), putamen (movement, learning), the hypothalamus (appetite, body temperature) and the amygdala (emotions). When a specific cannabinoid or combination of cannabinoids bind to a specialized receptor, an event or a series of events, is triggered in the cell, resulting in a change in the cell’s activity, its gene regulation and/or the signals that it sends to neighboring cells. This process is called “signal transduction.”
Clinical endocannabinoid deficiency (CEDC) is a proposed spectrum disorder that has been implicated in a range of illnesses, including fibromyalgia, migraine and irritable bowel syndrome. So far, very little clinical research has been conducted on this speculative disorder. It is quite possible that these very common conditions may respond favorably to cannabinoid therapies. However, this will only happen if more research is conducted.
The concept of the entourage effect was introduced in 1998 by Israeli scientists Shimon Ben-Shabat and Raphael Mechoulam. The theory is that cannabinoids within the cannabis plant work together through a network of coincidental relationships as part of a greater organism and affect the body in a mechanism similar to the body’s own endocannabinoid system. Basically, these compounds work better together than in isolation.
The longstanding, successful use of cannabis as a whole makes it necessary to find a rationale for its medicinal superiority in comparison to products containing isolated, single components of the cannabis plant, or synthetic cannabinoids trying to replicate the natural components.
Research on the benefits of THC and CBD in isolation is well established. THC demonstrates analgesic, anti-emetic, and anti-inflammatory properties. CBD possesses anti-psychotic, anti-seizure, and anti-anxiety properties. However, evidence is mounting that by isolating these cannabinoids or creating them in a lab, that the resulting effects may have limited therapeutic use. It is also the reason visits to a doctor or emergency room have increased. When delivered in high concentrations, THC can cause overdosing. Although an acute THC overdose rarely requires medical intervention, the side effects can be very unpleasant. Good evidence now shows that THC and CBD work together. CBD is known to lock out THC at the CB1-R. Therefore, applying the entourage effect, increasing CBD in the case of an overdose may lessen the effects of THC.
The synthetic cannabinoid, Marinol, is another example. Marinol is a pure, synthetic form of THC. When the drug was first introduced in the mid-80s, it was thought it would have the same effect as the cannabis plant as a whole. However, it soon became clear that most patients were not responding the same as when THC is consumed by smoking or ingesting naturally-grown cannabis. Researchers soon realized that other compounds, such as CBD and various terpenes, play a larger role than previously realized.
The passing of Medical Marijuana bills allows patients to obtain a medical marijuana card if they have a qualifying medical condition and a licensed physician believes they are likely to receive therapeutic or palliative benefit from the use of medical marijuana. Some conditions to consider.
Sickle Cell Anemia
Post-Traumatic Stress Disorder (PTSD)
The treatment of these conditions; or a chronic or debilitating disease or medical condition or its treatment that produces one or more of the following: cachexia or wasting syndrome, severe and chronic pain, severe nausea, seizures (including but not limited to those characteristic of epilepsy), or severe and persistent muscle spasms (including but not limited to those characteristic of multiple sclerosis).
Dr. Joseph Rosado, MD
Dr. Rudolph Moise, MD
N. Florida/Central Florida
Dr. Terel Newton, MD
National Physician Network
Heally: MMJ Doctors
Dr. Michael J. McKenzie, MD
Compassionate Cannabis Clinic-Venice
Dr. Barry Gordon, MD
CBD is not an acronym it stands for cannabidiol the name of the entire group of chemical compounds also known as cannabinoids which can be found naturally in the cannabis and hemp plant. Cannabis plants contain THC the psychoactive chemical that provides the "high" or "euphoria effect". Many varieties of cannabis are grown for medical purposes specifically and are bred to have a high CBD and very low THC content. The THC acts as a driver for the CBD which is commonly known as the "entourage effect". Strains are created for specific medical conditions and when titrated just right will provide relief and immediate benefit for patients.
CBD is an anti-inflammatory agent. It is not the same as THC. CBD has no side affects or contraindications. CBD has no psychotropic affect. So whatever you are taking for various health and physical issues you do not have to worry about adverse drug interactions.
Hemp is a plant that happens to be the kissing cousin of the cannabis plant. A negligible amount of THC is contained in the hemp plant therefore, we don't recommend trying to smoke it Hemp has over 25,00 applications which include such things as dietary supplements, skin products, clothing, textile, and accessories.
Have you ever wondered why cannabis has a distinct sometimes skunky smell. Well blame it on the terpenes. Terpenes provide each plants distinctive scent or essence. Like roses or spices different strains of Cannabis have unique odors ranging from sweet to acrid and skunky to floral. Scientists believe that terpenes account for some of the medical benefits of Cannabis including painkilling and anti-inflammatory effects.
There are three classes of the flowering Cannabis plant. Today we will discuss Cannabis Sativa vs. Cannabis Indica. Sativa tend to be rich in THC while Indica tend to be abundant in other cannabinoids. Indica strains generally provide a sense of deep body relaxation. Sativa strains tend to provide a more energizing experience. If you want a combination of the two in a variety of ways the strain is called a hybrid.
Inhalation is the fastest acting method to get the benefit from taking the medicine quickly. When inhaled, the active ingredients of Cannabis pass directly into the bloodstream from the lungs. Typically one can feel the effect between 5-20 minutes. Vaporizers are the preferred method for rapid relief of inhalation without the toxic and carcinogenic by-products of smoking.